The Simpsons episode titled "Marge in Chains' aired May 6, 1993, as part of Season 4.

According to Simpsons Fandom;

After many of Springfield's residents purchase a 'Juice Loosener', which are shipped from Japan, the dreaded Osaka Flu hits the town. Many of the townspeople are affected by the illness.

Furthermore, the episode also featured "Killer Bees," resembling the news of 'Murder Hornets' arriving in America.

Credit: rob martin via YouTube